Author

Sebastian Unic

University of StuttgartORCID 0000-0003-1671-0368Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Julian KönigiD· 2 shared Kathi ZarnackiD· 2 shared Monika Kuban· 2 shared Stefan LegewieiD· 2 shared Andrei Thomas‐TikhonenkoiD· 1 shared Anke BuschiD· 1 shared Anna OrekhovaiD· 1 shared Bea Spiekermann· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersSystems Biology

Julian KönigORCID

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2 papers

Recent·Most cited

Systems BiologybioRxivPreprintMar 6, 2025

Context-dependent effects of mutations on complex splicing decisions

Congxin Li, Sebastian Unic, Monika Kuban…·Stefan Legewie

The paper uses kinetic modeling and statistical learning to quantify how mutations affect splicing outcomes, revealing context-dependent isoform changes and cryptic splice site activation.

DOI 10.1101/2025.03.06.641829

humanbulk RNA-seq

𝕏 PostBluesky

Molecular BiologyNature CommunicationsPeer-reviewedSep 22, 2022

High-throughput mutagenesis identifies mutations and RNA binding proteins controlling CD19 splicing and CART-19 therapy resistance

Mariela Cortés-López, Laura Schulz, Mihaela Enculescu…·Julian König

The paper identifies mutations and RNA-binding proteins affecting CD19 splicing and CART-19 therapy resistance through high-throughput mutagenesis and mathematical modeling.

60 citationstop 4%

humanexperimental assay

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