Author

Monika Kuban

University of Stuttgart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Stefan LegewieiD· 3 shared Julian KönigiD· 2 shared Kathi ZarnackiD· 2 shared Sebastian UniciD· 2 shared Andrei Thomas‐TikhonenkoiD· 1 shared Anke BuschiD· 1 shared Anna OrekhovaiD· 1 shared Bea Spiekermann· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

Stefan LegewieORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CRISPR gene and transcriptome engineering (CRISPRgate) improves loss-of-function genetic screening approaches

Jannis Stadager, Chiara Bernardini, Laura Hartmann, Henrik May, Jessica Wiepcke, Monika Kuban, Zeynab Najafova, Steven A. Johnsen, Stefan Legewie, Franziska R. Traube, Julian Jude, Philipp Rathert

CRISPRgate improves loss-of-function screening by combining CRISPRko and CRISPRi to enhance gene repression and reduce noise in genetic studies.

Cell Reports Methods · Jun 1, 2025Peer-reviewedBiochemistry

Context-dependent effects of mutations on complex splicing decisions

Congxin Li, Sebastian Unic, Monika Kuban, Mirko Brüggemann, Julian König, Kathi Zarnack, Stefan Legewie

The paper uses kinetic modeling and statistical learning to quantify how mutations affect splicing outcomes, revealing context-dependent isoform changes and cryptic splice site activation.

bioRxiv · Mar 6, 2025 · PreprintSystems Biology

High-throughput mutagenesis identifies mutations and RNA binding proteins controlling CD19 splicing and CART-19 therapy resistance

Mariela Cortés-López, Laura Schulz, Mihaela Enculescu, Claudia Paret, Bea Spiekermann, Mathieu Quesnel-Vallières, Manuel Torres-Diz, Sebastian Unic, Anke Busch, Anna Orekhova, Monika Kuban, Mikhail V. Mesitov, Miriam M. Mulorz, Rawan Shraim, Fridolin Kielisch, , Julian König

The paper identifies mutations and RNA-binding proteins affecting CD19 splicing and CART-19 therapy resistance through high-throughput mutagenesis and mathematical modeling.

Nature Communications · Sep 22, 2022Peer-reviewedMolecular Biology