Context-dependent effects of mutations on complex splicing decisions
Congxin Li, Sebastian Unic, Monika Kuban, Mirko Brüggemann, Julian König, Kathi Zarnack, Stefan Legewie
The paper uses kinetic modeling and statistical learning to quantify how mutations affect splicing outcomes, revealing context-dependent isoform changes and cryptic splice site activation.
bioRxiv · Mar 6, 2025 · PreprintSystems Biology