Hiroki Nagai

This study identifies Xrp1 as a key driver of damage-induced cellular plasticity in Drosophila enteroendocrine cells, enabling dedifferentiation and re-differentiation during regeneration.

This study shows that BubR1 and Mad2 regulate midgut remodeling in Drosophila diapause by promoting cell cycle arrest in intestinal stem cells, which is essential for survival under adverse conditions.

This study introduces highly regenerative species-specific genes into Drosophila to improve stem cell function and extend lifespan by enhancing gut barrier functions during aging.

The paper shows nutrient fluctuations induce dedifferentiation of enteroendocrine cells into intestinal stem cells in Drosophila, promoting adaptive intestinal growth.