Petra Schwarz

This study identifies GLUL upregulation and altered glutamate/glutamine metabolism in prion-infected skeletal muscle, distinct from other neurodegenerative diseases.

This study screens alkaline and oxidative formulations for prion inactivation using a novel steel-bead seed amplification assay, identifying effective detergents for medical instrument decontamination.

This study identifies an H-latch conformational switch in PrPC that drives prion toxicity and shows that disrupting this switch can protect against prion-related neurodegeneration.

The paper shows that glial activation in prion diseases is nonautonomous, requiring neuronal PrPSc to drive neural dysfunction.

This study uses ribosome profiling to show that prion disease causes minor translational changes in neurons but significant changes in glia, overlapping with other neurodegenerative diseases.

The paper identifies early molecular changes in prion-infected mice, suggesting glial pathophysiology as a key driver and potential targets for intervention.

This study shows that synaptic accumulation of FUS in ALS-FUS mice leads to age-dependent misregulation of inhibitory synapses, suggesting a role in early neurodegeneration.

This study demonstrates that peptoid-conjugated beads can capture and transmit prion infectivity from blood, validating a sensitive assay for prion detection.