Author

Sonu Sahadevan

University of Zurich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Developmental Biology· 1

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Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Magdalini PolymenidouiD· 3 shared Katharina HembachiD· 2 shared Luc DupuisiD· 2 shared Marián Hruška-PlocháňiD· 2 shared Mark D. RobinsoniD· 2 shared Pierre De RossiiD· 2 shared Adriano AguzziiD· 1 shared Albert Christian LudolphiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersNeuroscience

Magdalini PolymenidouORCID

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Author profile →

4 papers

Recent·Most cited

Refate identifies chemical compounds to target trans-regulatory networks for cellular conversion

Di Xiao, Sonu Sahadevan, Melissa M. Mangala, Hani Jieun Kim, Anna Fredericks, Hao Huang, Raja Jothi, Patrick Tam, Anai Gonzalez-Cordero, Katherine G. Zyner, Pengyi Yang

Refate identifies chemical compounds targeting trans-regulatory networks to enable cellular conversion by integrating single-cell data and drug databases.

bioRxiv · Jul 9, 2025 · PreprintDevelopmental Biology

Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD

Marián Hruška-Plocháň, Katharina M. Betz, Silvia Ronchi, Vera I. Wiersma, Zuzanna Maniecka, Eva‐Maria Hock, Florent Laferrière, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Martina Panatta, Alexander van der Bourg, Dáša Bohačiaková, Karl Frontzek, Adriano Aguzzi, , Magdalini Polymenidou

The paper develops a human iPSC-derived neural model to study TDP-43 pathology, identifying NPTX2 misregulation as a key factor in ALS/FTLD neurotoxicity.

bioRxiv · Dec 8, 2021 · PreprintNeuroscience

Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses

Jelena Scekic‐Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa W. Y. Kan, Salim Megat, Pierre De Rossi, Stéphane Dieterle, Raphaelle Cassel, Marguerite Jamet, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valérie Demais, Sonu Sahadevan, Katharina Hembach, Hans‐Peter Müller, , Luc Dupuis

This study shows that cytoplasmic FUS mislocalization in mice causes behavioral changes and inhibitory synaptic defects without widespread neuronal loss.

Nature Communications · May 21, 2021Peer-reviewedNeuroscience

Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice

Sonu Sahadevan, Katharina Hembach, Elena Tantardini, Manuela Pérez‐Berlanga, Marián Hruška-Plocháň, Julien Weber, Petra Schwarz, Luc Dupuis, Mark D. Robinson, Pierre De Rossi, Magdalini Polymenidou

This study shows that synaptic accumulation of FUS in ALS-FUS mice leads to age-dependent misregulation of inhibitory synapses, suggesting a role in early neurodegeneration.

bioRxiv · Jun 10, 2020 · PreprintNeuroscience