Davide Caredio

Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex

The paper identifies TFAP2C as a genetic interactor of hnRNP K, showing their roles in mTOR metabolic regulation and a causal link to prion propagation.

Control of Prion Uptake by Bone Morphogenetic Protein Signaling

The paper identifies BMP signaling as a regulator of prion uptake by screening for genetic modifiers in human cells and shows that modulating BMP components affects prion internalization.

Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone

This study uses quantitative 3D histochemistry to show that netoglitazone reduces amyloid-beta plaques in specific brain regions of a mouse AD model.

Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion Disease

The paper identifies Gpnmb as a marker of a phagocytic microglial state linked to neuronal loss in prion disease, showing its role in clearing apoptotic cells.

Prion diseases disrupt the glutamate/glutamine metabolism in skeletal muscle

This study identifies GLUL upregulation and altered glutamate/glutamine metabolism in prion-infected skeletal muscle, distinct from other neurodegenerative diseases.