Tomas P Olsson

This study analyzes ancient DNA from three European sites to assess the genomic impact of the second plague pandemic, finding no strong positive selection but evidence of reduced long-range immigration post-pandemic.

This study identifies DNA methylation changes in cerebrospinal fluid cells from MS patients, linking them to immune regulatory alterations and implicating protocadherins in MS pathogenesis.

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

The paper predicts combination therapies for MS by modeling patient-specific signaling networks using phosphoproteomics data and identifies TAK1 as a co-druggable target.

This study examines the genetic structure of the Norwegian population, identifying two distinct genetic regions and highlighting the impact of geography on migration patterns and ancestry.

The paper profiles small non-coding RNAs in multiple compartments of MS patients and controls, identifying distinct sncRNA expression patterns in CSF and PBMCs that suggest organ-specific regulatory mechanisms.

The paper benchmarks disease module identification methods using GWAS and validates a multi-omic module strongly associated with multiple sclerosis risk factors.

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.