Vincent van Hoef

The paper shows that CD4 T cell surface protein organization predicts response to anti-PD-1 therapy in NSCLC, outperforming protein abundance alone.

The paper introduces PNA, a DNA-based method to map protein organization and interactions in single cells, revealing abundance, clustering, and colocalization relationships.

This study shows estrogen receptor alpha (ER) regulates gene expression by coordinating transcription with translational offsetting, maintaining protein levels despite changes in mRNA abundance.

This paper presents an optimized non-linear sucrose gradient method for polysome-profiling that reduces sample handling and enables translatome analysis from small tissue samples and primary cells.