BiophysicsbioRxivPreprint
Single-molecule assay reveals the impact of composition, RNA duplex, and inhibitors on the binding dynamics of SARS-CoV-2 polymerase complex
Terri C. Lovell, Heidi A. F. Dewling, Cynthia X. Li…·Gonzalo Cosa
This study uses a single-molecule assay to analyze the binding dynamics of SARS-CoV-2 polymerase complex subunits with RNA, revealing differences in binding stability between co-expressed and reconstituted complexes and the effects of inhibitors.
DOI 10.1101/2025.01.10.632212