Johannes Smolander

This study shows that disrupting the CIP2A gene reduces T cell-driven inflammation in experimental autoimmune encephalomyelitis.

Coralysis improves integration of imbalanced cell types and states in single-cell data by multi-level integration, outperforming existing methods in such scenarios.

Totem is an R package that automates tree-shaped trajectory inference from single-cell data by generating and evaluating multiple clustering results.

This study benchmarks 18 methods for detecting differential states in multi-subject scRNA-seq data, finding that pseudo-bulk and mixed models outperform naive single-cell approaches by reducing false positives.

scShaper is a fast and accurate linear trajectory inference method for single-cell RNA-seq data, outperforming existing methods in accuracy and generalizability.

ILoReg improves cell population identification in single-cell RNA-seq by using probabilistic feature extraction before clustering.

The paper identifies DNA methylation differences in peripheral blood of Alzheimer’s disease discordant twin pairs, linking these to brain gene expression and neuronal functions.