Author

Thomas V. Karathanos

Stanford MedicineORCID 0000-0003-1754-3872Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1

Frequent Co-Authors

Aaron M. HorningiD· 3 shared Annika K K WeimeriD· 3 shared Christina N. CurtisiD· 3 shared Edward D. EspliniD· 3 shared Emma MonteiD· 3 shared James M. FordiD· 3 shared Jeanne SheniD· 3 shared Meredith A. MillsiD· 3 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Aaron M. HorningORCID

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3 papers

Recent·Most cited

Cancer BiologyNaturePeer-reviewedNov 25, 2025

Polyclonal origins of human premalignant colorectal lesions

Debra Van Egeren, Ryan O. Schenck, Aziz Khan…·Christina N. Curtis

This study shows that many premalignant colorectal polyps contain multiple genetic lineages, indicating polyclonal origins rather than single-cell expansion.

10 citationstop 4%

humanwhole-genome sequencing

𝕏 PostBluesky

Cancer BiologybioRxivPreprintNov 20, 2024

Single-cell spatial mapping reveals alteration of tissue microenvironment during early colorectal cancer

Tuhin Kumar Guha, Edward D. Esplin, Aaron M. Horning…·Michael P. Snyder

The paper uses spatial CODEX experiments to show early colorectal cancer microenvironment changes in FAP, including CAFs, immune suppression, and beta-catenin nuclear translocation.

DOI 10.1101/2024.11.20.622725

humanspatial transcriptomics

𝕏 PostBluesky

GenomicsNature CancerPeer-reviewedOct 30, 2024

Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis

Yizhou Zhu, Hayan Lee, Shannon M. White…·Michael P. Snyder

This study shows that early colorectal cancer loses promoter-enhancer connectivity, leading to gene expression changes and a two-phase model of transcriptional regulation.

23 citations

humanChIP-seq

𝕏 PostBluesky