Author

Yu Luan

The University of Texas at San Antonio Health Science CenterORCID 0000-0003-1778-9071Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Michael H Nipper· 2 shared Pei WangiD· 2 shared Yi XuiD· 2 shared Angel A. Dominguez· 1 shared Baozhen ZhangiD· 1 shared Chenhui He· 1 shared Daohong ZhouiD· 1 shared David J. DeGraffiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Michael H Nipper

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologyJournal of Clinical InvestigationPeer-reviewedJan 1, 2026

NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress

Yi Xu, Michael H Nipper, Angel A. Dominguez…·Pei Wang

This study identifies NF2 as a critical tumor suppressor in PDAC, showing its role in promoting invasive behavior, enhancing cell fitness under stress, and contributing to drug resistance.

5 citationstop 1%

humanorganoid / primary culture

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Developmental BiologyeLifePeer-reviewedJun 17, 2024

Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation

Yifan Wu, Kunhua Qin, Yi Xu…·Pei Wang

This study shows that Hippo pathway-mediated YAP1/TAZ inhibition is essential for pancreatic endocrine specification and differentiation, but not for beta-cell function.

11 citations

mousestatistical model

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GenomicsGenome biologyPeer-reviewedApr 15, 2021

Subtype-specific epigenomic landscape and 3D genome structure in bladder cancer

Tejaswi Iyyanki, Baozhen Zhang, Qixuan Wang…·Feng Yue

This study identifies subtype-specific epigenomic and 3D genome structures in bladder cancer, linking NPAS2 to luminal subtype regulation and clinical outcomes.

58 citations

humanbulk RNA-seq

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