Author

Baozhen Zhang

Peking University Cancer HospitalORCID 0000-0002-2307-9773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Assay:Hi-C· 1

Frequent Co-Authors

Dajun DengiD· 3 shared Chenghua Cui· 2 shared Liankun GuiD· 2 shared Sisi Qin· 2 shared Ying GaniD· 2 shared David J. DeGraffiD· 1 shared Fan Song· 1 shared Feng YueiD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMolecular Biology

Dajun DengORCID

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Author profile →

4 papers

Recent·Most cited

Subtype-specific epigenomic landscape and 3D genome structure in bladder cancer

Tejaswi Iyyanki, Baozhen Zhang, Qixuan Wang, Ye Hou, Qiushi Jin, Jie Xu, Hongbo Yang, Tingting Liu, Xiaotao Wang, Fan Song, Yu Luan, Hironobu Yamashita, Ruby Chien, Huijue Lyu, Lijun Zhang, , Feng Yue

This study identifies subtype-specific epigenomic and 3D genome structures in bladder cancer, linking NPAS2 to luminal subtype regulation and clinical outcomes.

Genome biology · Apr 15, 2021Peer-reviewedGenomics

T606-phosphorylation deprives the function of Kaiso as a transcription and oncogenic factor

Wei Tian, Hongfan Yuan, Sisi Qin, Wensu Liu, Baozhen Zhang, Liankun Gu, Jing Zhou, Dajun Deng

This study shows that AKT1 phosphorylates Kaiso at T606, promoting its cytoplasmic localization and de-repression of CDH1, with reduced phosphorylation linked to gastric cancer progression.

bioRxiv · Mar 23, 2020 · PreprintMolecular Biology

Hydroxymethylated-P16 Allele Is Transcription-Inactive

Ying Gan, Paiyun Li, Xiao Han, Sisi Qin, Chenghua Cui, Zhaojun Liu, Jing Zhou, Liankun Gu, Zheming Lu, Baozhen Zhang, Dajun Deng

This study shows that hydroxymethylated P16 alleles are transcriptionally inactive, demonstrated through engineered P16-specific dioxygenase-induced hydroxymethylation and its effects on cell growth and migration.

bioRxiv · Apr 24, 2019 · PreprintMolecular Biology

Effects of P16 DNA Methylation on Proliferation, Senescence, and Lifespan of Human Fibroblasts

Ying Gan, Chenghua Cui, Shengyan Xiang, Baozhen Zhang, Dajun Deng

This study shows that P16 DNA methylation prevents senescence, promotes proliferation, and extends lifespan in human fibroblasts, potentially contributing to cancer development.

bioRxiv · Aug 30, 2018 · PreprintCell Biology