A multiplex platform to identify mechanisms and modulators of proteotoxicity in neurodegeneration
Samuel J. Resnick, Seema Qamar, Jenny Sheng, Lei Haley Huang, Jonathon Nixon‐Abell, Schuyler M. Melore, Chyi Wei Chung, Xuecong Li, Jingshu Wang, Nancy Ruonan Zhang, Neil A. Shneider, Clemens F. Kaminski, Francesco Simone Ruggeri, Gabriele S. Kaminski Schierle, Peter St George‐Hyslop, Alejandro Chavez
The paper develops a multiplex reverse genetics platform to identify genetic modifiers of protein misfolding in neurodegenerative diseases and identifies DNAJB6 as a modifier of toxicity and solubility of ALS/FTD-linked RNA-binding proteins.
bioRxiv · Sep 19, 2022 · PreprintNeuroscience