Gaizun Hu

Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus organization

This study identifies Pcdh20 as a POU2F3 target gene essential for tuft cell microvillus structure, showing its role in maintaining microvillar rigidity and organization.

The Septin Cytoskeleton is a Novel Regulator of Intestinal Epithelial Barrier Integrity and Mucosal Inflammation

This study investigates the role of SEPT9 in intestinal epithelial barrier integrity and inflammation, finding that its loss disrupts tight junctions and increases susceptibility to colitis.

Tear secretion via a paracellular pathway in lacrimal gland is regulated by myosin-mediated modulation of tight junction permeability

This study identifies a paracellular water secretion pathway in the lacrimal gland regulated by non-muscle myosin IIC, which modulates tight junction permeability and can be targeted for dry eye treatment.

Transmembrane channel-like 4 and 5 proteins at microvillar tips are potential ion channels and lipid scramblases

The paper identifies TMC4 and TMC5 at microvillar tips and suggests they may function as ion channels and lipid scramblases, similar to mechanotransduction complexes in stereocilia.

Potential role of fructose on human colon DNA methylation in racial disparities observed for colorectal cancer risk.

The paper identifies fructose-associated DNA methylation changes in AA colon tissue linked to CRC risk, showing greater effects in right-side colon.