Blanca Díaz Castro

3BTRON is a deep learning framework that automatically analyzes electron microscopy images to distinguish BBB structures in aged versus young mouse brains, achieving 77.8% sensitivity and 80.0% specificity.

The paper identifies the prefrontal cortex as the most vulnerable BBB region to ageing in mice by analyzing molecular, structural, and functional changes across three brain regions.

This study examines how neuroinflammation affects astrocyte gene expression in the mouse medial prefrontal cortex and links these changes to anhedonia, finding shared pathways with human major depressive disorder and Alzheimer's disease.