Richard Joseph White

The paper identifies manganese deficiency and neurotoxicity in zebrafish slc39a14 mutants through transcriptome analysis, revealing key molecular pathways involved in manganese homeostasis disruption.

The paper shows that in zebrafish, differentially expressed genes near a mutation may not be caused by the mutation due to allele-specific expression, leading to misinterpretation of RNA-seq results.

The paper identifies the core gene module required for neural crest induction and reveals the transcriptional basis of genetic compensation via paralogues in zebrafish.

RNA-seq and 3′ end counting over 18 zebrafish stages (1-cell to day 5) profile 23,642 genes; over 100 chromosome 4 zinc finger genes peak at zygotic genome activation.