Derek L. Stemple

Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

The paper identifies Slit3 as a genetic locus influencing nicotine preference in zebrafish and smoking behavior in humans through mutagenesis screens and SNP analysis.

Targeted gene correction of FKRP by CRISPR/Cas9 restores functional glycosylation of α-dystroglycan in cortical neurons derived from human induced pluripotent stem cells

This paper corrects FKRP mutations in iPSCs using CRISPR/Cas9, restoring functional glycosylation of α-dystroglycan in cortical neurons and validating the role of FKRP in dystroglycanopathies.

The gene regulatory basis of genetic compensation during neural crest induction

The paper identifies the core gene module required for neural crest induction and reveals the transcriptional basis of genetic compensation via paralogues in zebrafish.

Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependant pigment progenitors in zebrafish

The paper identifies Endothelin receptor Aa as a regulator of APSC quiescence in zebrafish, linking blood vessel signals to pigment cell differentiation.

A high-resolution mRNA expression time course of embryonic development in zebrafish

RNA-seq and 3′ end counting over 18 zebrafish stages (1-cell to day 5) profile 23,642 genes; over 100 chromosome 4 zinc finger genes peak at zygotic genome activation.