Cancer BiologybioRxivPreprint
BRCA2 loss drives a PKM1-dominant glycolytic state that is selectively lethal to pyruvate kinase activation
Maira Di Tano, Mujmmail Ahmed, Shiri Li…·Marcus DaSilva Goncalves
The paper shows BRCA2 loss leads to a PKM1-dominant glycolytic state that can be targeted with PKM activators to kill HRD tumors.
DOI 10.64898/2026.09.29.754041