Carolina E. Echeverría

The paper shows BRCA2 loss leads to a PKM1-dominant glycolytic state that can be targeted with PKM activators to kill HRD tumors.

This study shows that inhibiting fructose metabolism via KHKi reduces weight gain and enhances weight loss when combined with GLP-1 receptor agonism in mice.

This study examines how chronic fructose exposure alters metabolism in prostate cancer cells, revealing cell-type-specific metabolic shifts and identifying Glut-5 and lipid pathways as potential therapeutic targets.