Marcus DaSilva Goncalves

BRCA2 loss drives a PKM1-dominant glycolytic state that is selectively lethal to pyruvate kinase activation

The paper shows BRCA2 loss leads to a PKM1-dominant glycolytic state that can be targeted with PKM activators to kill HRD tumors.

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila

The paper shows that lipid metabolism in Drosophila hepatocyte-like cells supports intestinal tumor growth through the TORC1-Hnf4 pathway, with potential therapeutic implications for cancer-associated metabolic dysfunction.

Intestinal fructose metabolism drives unsaturated fat absorption and synergizes with GLP-1 receptor agonism to promote weight loss

This study shows that inhibiting fructose metabolism via KHKi reduces weight gain and enhances weight loss when combined with GLP-1 receptor agonism in mice.

JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food Intake

This study shows that JAK1/2 inhibition with ruxolitinib improves survival and body weight in lung cancer models by increasing food intake and restoring metabolic function.

Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer

The paper identifies a cytokine-lipid axis that links systemic inflammation to hepatic autophagy dysfunction in cancer across species.

Sustained Glucose Turnover Flux Distinguishes Cancer Cachexia from Nutrient Limitation

This study identifies sustained glucose turnover flux as a distinguishing metabolic feature of cancer cachexia compared to nutrient limitation under controlled food intake.

Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities

This study develops a pan-cancer PDO platform to preserve tumor heterogeneity and identify therapeutic vulnerabilities, finding that 58% of PDOs respond to Talazoparib and combination screens reveal resistance-overcoming drugs.

Tumor Cytokine-Induced Hepatic Gluconeogenesis Contributes to Cancer Cachexia: Insights from Full Body Single Nuclei Sequencing

The paper shows that tumor-secreted cytokines induce hepatic gluconeogenesis, contributing to hyperglycemia and poor prognosis in cancer cachexia using Drosophila and mouse models.

A global atlas of substrate specificities for the human serine/threonine kinome

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.