BRCA2 loss drives a PKM1-dominant glycolytic state that is selectively lethal to pyruvate kinase activation
Maira Di Tano, Mujmmail Ahmed, Shiri Li, Michael Lyashenko, Neil G. Ruthen, Ethan Tse, Isaac Nathoo, Carolina E. Echeverría, Jack Sanford, A. M. Saleh, Jeshua Kim, Ezequiel Carlos Dantas, Davide Pradella, Rhee Kyu, Ed Reznik, , Marcus DaSilva Goncalves
The paper shows BRCA2 loss leads to a PKM1-dominant glycolytic state that can be targeted with PKM activators to kill HRD tumors.
bioRxiv · Sep 29, 2026 · PreprintCancer Biology