Toti is a multi-omics database that provides epigenetic and transcriptomic resources for studying totipotent stem cells, offering tools for exploration and analysis.

Stem Cell Reports · Aug 21, 2025Peer-reviewedDevelopmental Biology

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease

Niina Sandholm, Joanne B. Cole, Viji Nair, Xin Sheng, Hongbo Liu, Emma Ahlqvist, Natalie R. van Zuydam, Emma H. Dahlström, Damian Fermin, Laura Jane Smyth, Rany M. Salem, Carol M. Forsblom, Erkka Valo, Valma Harjutsalo, Eoin Patrick Brennan, , Per‐Henrik Groop

Diabetologia · Jun 28, 2022Peer-reviewedGenetic & Genomic Medicine

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

Xin Sheng, Yuting Guan, Ziyuan Ma, Junnan Wu, Hongbo Liu, Chengxiang Qiu, Steven Vitale, Zhen Miao, Matthew J. Seasock, Matthew Palmer, Myung K. Shin, Kevin L. Duffin, Steven S. Pullen, Todd L. Edwards, Jacklyn N. Hellwege, , Katalin Suszták

The paper maps genetic variants to cell types in the kidney to identify disease mechanisms and drug targets.

Nature Genetics · Aug 12, 2021Peer-reviewedGenetics

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

Marijana Vujković, Jacob M. Keaton, Julie Ann Lynch, Donald R. Miller, Jin J. Zhou, Catherine Tcheandjieu, Jennifer E. Huffman, Themistocles L. Assimes, Kimberly Lorenz, Xiang Zhu, Austin T. Hilliard, Renae Judy, Jie Huang, Kyung Min Lee, Derek M. Klarin, , Saib S. Gappy

Multi-ethnic type 2 diabetes (T2D) meta-analysis of 228,499 cases and 1,178,783 controls finds 318 previously unreported loci, 804 expression-colocalized genes, and 13 SNP-by-T2D vascular-outcome interactions.

Nature Genetics · Jun 15, 2020Peer-reviewedGenetic & Genomic Medicine✦ In-depth digest