Dali Li

This study demonstrates that dual-gene AAV therapy restores metabolic function and shows long-term safety in a mouse model of propionic acidemia.

This paper introduces REDMAPCre, a red-light-activated Cre recombinase system that enables rapid and efficient DNA recombination in mammalian cells and mice.

This paper develops eTd-mtABEs, engineered mitochondrial A-to-G base editors with enhanced efficiency and targeting scope, enabling efficient generation of mtDNA disease models in rat embryos.

The paper identifies novel structural variants in Han Chinese genomes using long-read sequencing and links them to phenotypic diversity and disease susceptibility.

The paper demonstrates the production of offspring from oocytes derived from mouse spermatogonial stem cells through chromatin reorganization and identifies key factors involved in germline stem cell conversion.