Ziyuan Ma

Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6-Dependent Interneuron Dysmaturation

This study uses human brain organoids to show that transient IL-6 exposure during prenatal development disrupts interneuron maturation and subtype specification, linking it to neurodevelopmental disorders.

Neurogenin-2 Reprograms Human Microglial Lineage Cells into Neurons In Vitro and in Chimeric Brains

This study shows that NEUROG2 can reprogram human microglial lineage cells into neurons both in vitro and in vivo, revealing a new pathway for neuronal replacement.

Human-Mouse Chimeric Brain Models to Study Human Glial-Neuronal and Macroglial-Microglial Interactions

This study uses human-mouse chimeric brain models to investigate glial-neuronal and macroglial-microglial interactions, revealing key molecular mechanisms and dynamic cellular behaviors.

A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimers Disease

This paper introduces a trisomy 21-linked CSF2RB mutation in microglia that reduces neuroinflammation and enhances phagocytic functions, offering potential for AD therapy.

Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression

Multi-omic and spatial profiling of 81 human kidney samples resolves four tissue microenvironments; the fibrotic one's gene signature is reported to beat histopathology at predicting outcome.

Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimers Disease

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

The paper maps genetic variants to cell types in the kidney to identify disease mechanisms and drug targets.

Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets

The paper maps the regulatory landscape of the mouse kidney at single cell resolution, identifying key transcription factors and regulatory circuits, and linking variants to kidney disease.