Ragnhildur Thóra Káradóttir

Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport

The paper identifies myelin basic protein (MBP) as an RNA chaperone that facilitates microglial nuclear import of myelin RNA, with implications for multiple sclerosis pathology.

Fatty acid binding protein-8 (FABP8/PMP2) reveals molecular heterogeneity of myelin sheaths in the human CNS

This paper identifies FABP8/PMP2 as a defining feature of human and old-world monkey CNS myelin, revealing molecular heterogeneity in myelin sheaths and its role in cholesterol enrichment.

Constitutive DREADD signalling modulates oligodendrocyte precursor cell bioelectrical membrane properties and fate

This study shows that constitutive DREADD signalling in oligodendrocyte precursor cells alters bioelectrical properties and fate, highlighting a confound in using DREADDs in small cells.

Substrate stiffness regulates neuronal maturation via Piezo1-mediated TTR activity

This study shows that substrate stiffness affects neuronal maturation by regulating Piezo1-mediated TTR activity, delaying synapse formation and electrical maturation.

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

The paper shows human astrocytes and microglia ingest more synapses in Alzheimer's disease via MFG-E8, and inhibiting MFG-E8 reduces this ingestion in cultured cells.

Signal requirement for cortical potential of transplantable human neuroepithelial stem cells

This study identifies six signaling pathways regulating the proliferation and developmental potential of human neuroepithelial stem cells in vitro.

Activity-dependent alteration of early myelin ensheathment in a developing sensory circuit

This study investigates how patterned visual experience affects early myelin ensheathment in Xenopus tadpoles by manipulating neuronal activity with strobe light and measuring calcium responses.

Gene editing in rat embryonic stem cells to produce in vitro models and in vivo reporters

This study uses CRISPR/Cas9 to edit rat embryonic stem cells, generating in vitro models and in vivo reporters for genetic studies.