Pierre J. Milpied

The paper investigates antibody maturation in germinal centers, finding that mechanical resistance of BCR-antigen bonds, not affinity, drives selection during maturation.

This study shows that plasmacytoid dendritic cells (pDCs) and their interferons are dispensable or harmful in systemic and respiratory viral infections in mice.

This study shows that signals from the bone marrow B cell niches influence pre-leukemic cell fate in murine B-ALL by altering proliferation and secondary mutation patterns.

SeQuoIA is a single-cell BCR sequencing pipeline that tracks selection mechanisms in germinal centres by inferring BCR-driven selection pressure from somatic mutation patterns.

This study identifies the transcriptional profile of circulating autoreactive CD4 T cells in autoimmune liver diseases and shows their functional relationship to liver-specific pathogenic clones.

The paper introduces a method to produce monoclonal antibodies from single B cells using FB5P-seq libraries for integrative analysis of B cell phenotype, transcriptome, and antigen receptor sequence.

The paper tracks GC-derived B cells in lymph nodes to identify PrePC cells and their transition to plasma cells, revealing spatial and transcriptional changes during differentiation.

ShIVA provides a user-friendly interface for biologists to analyze single-cell RNA-seq and CITE-seq data using Seurat v4, enabling reproducible analysis and visualization.