Antibody maturation in germinal centers selects mutants based on BCR-antigen bond mechanical resistance
Lama Awada, Jad Sleiman, Jean‐Marc Navarro, Rémy Torro, Martine Biarnes‐Pelicot, Eglantine Hector, Laurent Limozin, Chuang Dong, Pierre J. Milpied, Philippe Robert
The paper investigates antibody maturation in germinal centers, finding that mechanical resistance of BCR-antigen bonds, not affinity, drives selection during maturation.
bioRxiv · Mar 13, 2026 · PreprintImmunology