Author

Fangxiang Hu

Enzon Pharmaceuticals (United States)ORCID 0000-0002-7641-9882Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ákos NyergesiD· 2 shared Anush Chiappino-PepeiD· 2 shared Bogdan BudnikiD· 2 shared George McDonald ChurchiD· 2 shared Kangming CheniD· 2 shared Maximilien S. Baas-ThomasiD· 2 shared Min LiuiD· 2 shared Regan Flynn· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Ákos NyergesORCID

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2 papers

Recent·Most cited

Synthetic genomes unveil the effects of synonymous recoding

Ákos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien S. Baas-Thomas, Regan Flynn, Shirui Yan, Nili Ostrov, Min Liu, Meizhou Wang, Qingmei Zheng, Fangxiang Hu, Kangming Chen, Alexandra Rudolph, Xi Dawn Chen, Jenny J. Ahn, , George McDonald Church

This study uses synthetic genomes to investigate how synonymous codon recoding affects organismal fitness and develops a workflow to overcome lethal effects of codon swaps.

bioRxiv · Jun 16, 2024 · PreprintSynthetic Biology

Swapped genetic code blocks viral infections and gene transfer

Ákos Nyerges, Svenja Vinke, Regan Flynn, Siân V. Owen, Eleanor A. Rand, Bogdan Budnik, Eric C. Keen, Kamesh Narasimhan, Jorge A. Marchand, Maximilien S. Baas-Thomas, Min Liu, Kangming Chen, Anush Chiappino-Pepe, Fangxiang Hu, Michael Baym, George McDonald Church

The paper demonstrates a genetic code reassignment strategy that makes cells resistant to viral infections and prevents horizontal gene transfer by mistranslating viral proteins and relying on synthetic codons.

bioRxiv · Jul 8, 2022 · PreprintSynthetic Biology