Ákos Nyerges

This paper develops a genetically firewalled Escherichia coli commensal that blocks horizontal gene transfer and viral infections while maintaining high fitness in the gut.

This study uses synthetic genomes to investigate how synonymous codon recoding affects organismal fitness and develops a workflow to overcome lethal effects of codon swaps.

The paper improves a MAGE protocol to repair mutations in synthetic genome segments, enabling successful complementation of gene deletions in Escherichia coli.

The paper demonstrates a genetic code reassignment strategy that makes cells resistant to viral infections and prevents horizontal gene transfer by mistranslating viral proteins and relying on synthetic codons.

The paper introduces a method using bacterial insertion sequences to clone and amplify transgenes in bacterial chromosomes, demonstrating stability and copy-number control in Escherichia coli.

This study demonstrates how ssDNA recombineering in bacteria enables hyper-diversification of nanobodies, resulting in variants that recognize new antigens while retaining original specificity.

The paper examines features of a cyanobacterial regulatory node for optogenetic device interoperability between E. coli and P. putida, identifying translational control as a bottleneck and proposing optimization strategies.

This paper develops a CRISPR-interference system to silence bacterial mobile genetic elements, reducing their transposition rates and stabilizing synthetic constructs.

This study shows that enzyme promiscuity enables E. coli to adapt to novel substrates through computational modeling and lab evolution experiments.