Sam P. Brown

The paper examines how the timing of anti-CRISPR gene expression in phages affects CRISPR-Cas interactions, finding that spacers map to earlier positions in genomes containing anti-CRISPR systems.

This paper develops a computational pipeline to quantify antibiotic susceptibility and inoculum effects in Pseudomonas aeruginosa by analyzing transient dynamics and identifying a novel mathematical model.

The paper evaluates the specificity of canonical Pseudomonas aeruginosa genes associated with cystic fibrosis (CF) by comparing their mutational patterns across diverse clinical and environmental contexts.

The paper shows that Pseudomonas aeruginosa's apparent generalism is due to convergent, cryptic specialization across environments, not strict generalism or lineage-specific specialization.

This study shows that plasmid-borne CRISPR-Cas is beneficial in plasmid competition but is hindered by toxin-antitoxin systems in horizontally transferred plasmids.

The paper shows that using microbiome data improves predictive models of lung function in cystic fibrosis patients, with non-pathogenic taxa also contributing to predictions.

The paper shows that horizontal gene transfer of mobile genetic elements carrying public good genes can be favored by indirect selection when public goods benefit kin, promoting gene exchange among bacteria.