Tatsuro S. Takahashi

Firrm functions as a multiprotein interaction platform that coordinates Mcm8-9-Hrob recruitment and Fignl1-mediated Rad51 unloading

The paper identifies Firrm as a platform coordinating Mcm8-9-Hrob recruitment and Fignl1-mediated Rad51 unloading during homologous recombination.

Replication protein A prevents unregulated priming and Rad51 loading on single-stranded DNA in nuclear extracts of Xenopus eggs

This study shows that RPA prevents unregulated priming and Rad51 loading on ssDNA in Xenopus egg extracts, maintaining genome stability.

The Atad5 RFC-like complex is the major unloader of proliferating cell nuclear antigen in Xenopus egg extracts

The paper shows that Atad5-RLC is the major PCNA unloader in Xenopus egg extracts despite being a small fraction of RFC/RLCs.

The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5

This study identifies USP7 and ATAD5 as key factors in terminating UHRF1-dependent PAF15 ubiquitin signaling, linking this process to the completion of maintenance DNA methylation.

Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1

The paper shows that Cdt2 binds PCNA via a PIP box, enhancing CRL4Cdt2 activity and Cdt1 ubiquitination, suggesting a new mechanism for substrate targeting.