Marcos Siguero-Álvarez

This study identifies abnormal ventricular wall patterning as a driver of MYBPC3-related hypertrophic cardiomyopathy through disrupted cardiomyocyte proliferation and Prdm16 regulation.

The paper examines gene expression patterns in mouse ventricles, finding less complex regional organization compared to humans and highlighting spatial gene regulation in cardiomyopathy.

This study examines how MIB1 mutations in mice affect cardiac electrical activity, finding altered ion currents and prolonged action potential duration linked to arrhythmia risk.