José Luís de la Pompa

This study identifies abnormal ventricular wall patterning as a driver of MYBPC3-related hypertrophic cardiomyopathy through disrupted cardiomyocyte proliferation and Prdm16 regulation.

The paper examines gene expression patterns in mouse ventricles, finding less complex regional organization compared to humans and highlighting spatial gene regulation in cardiomyopathy.

This study examines how MIB1 mutations in mice affect cardiac electrical activity, finding altered ion currents and prolonged action potential duration linked to arrhythmia risk.

This study identifies NOTCH-dependent transcriptional and chromatin changes in mouse endocardium during valve development and disease, revealing cooperative interactions with the HIPPO pathway.

This study investigates the embryonic origin of coronary artery fistulas (CAFs) using animal models and shows that myocardial discontinuities in the ventricular wall cause CAF formation through abnormal epicardial-endocardial interactions.

This study identifies Nrg1-ErbB2/4-pErk signaling as critical for cardiomyocyte cell cycle progression, migration, and trabeculation during ventricular development, with implications for cardiac regeneration.

This study shows that Midkine-a promotes heart regeneration in zebrafish by regulating fibrosis, as its loss leads to persistent collagen scars and blocked regeneration.

This study shows that loss of Caveolin-1 in zebrafish leads to increased cardiac cell stiffness and impaired heart function, but allows for heart regeneration after injury.

This study identifies a Dll4-Jag1-EphrinB2 signaling cascade that regulates coronary arterial development in mice.

This study shows that deleting NOTCH-RBPJ in the myocardium does not impair heart development or function, but deleting it in both myocardial and endocardial progenitors causes cardiac defects.

This paper develops a human pluripotent stem cell model to study valvulogenesis and disease, showing it can recapitulate valve development and disease traits like mitral valve prolapse.

The paper identifies actomyosin dynamics and Notch/Bmp signaling as drivers of apical extrusion of proepicardial cells in zebrafish during heart development.