Tomas Strucko

This study investigates how Darwinian selection affects engineered traits in yeast by evolving strains with pigment production pathways under different carbon sources.

The paper uses genome-wide host-pathway interaction screens to identify metabolic targets for optimizing cis-cis-muconic acid production in yeast.

This study develops a CRISPR-Cas9 toolbox for efficient genetic engineering of Komagataella phaffii, enabling marker-free gene integration and high-efficiency mutagenesis.

CRI-SPA transfers genetic features between yeast strains to map sequence to function, demonstrating its ability to transfer genes for betaxanthin production across a yeast knock-out collection.