Samuel G. Rodriques

This paper introduces an AI system for automated small molecule structure elucidation from NMR spectra, combining generative models with reasoning agents to outperform existing tools.

The paper introduces microProteomEx, a platform combining tissue expansion, imaging, and proteomics to achieve high-resolution spatial proteomics in hard tissues and clinical samples.

The paper introduces PRISM, a platform that uses combinatorial protein barcodes to enable self-correcting neuron tracing with molecular context, improving tracing accuracy and handling spatial gaps.

The paper shows that astrocytic RNA editing via ADAR1 modulates immune responses to alpha-synuclein, contributing to neuroinflammation in Parkinson's disease.

Fleming is an AI agent that identifies lead compounds for Mycobacterium tuberculosis by combining discriminative and generative models, achieving higher discrimination and hit rates than alternative approaches.

This paper introduces T2, a method using RNA editing to estimate transcriptional age and identify transient transcriptional programs in human cells.

HyPR-seq sensitively quantifies up to 100 chosen genes in single cells, achieving high sensitivity for individual transcripts and reducing costs compared to whole-transcriptome scRNA-seq.

This paper introduces RNA timestamps to infer RNA age using A-to-I editing, enabling temporal analysis of gene expression in single-cell RNA sequencing.

Slide-seq measures genome-wide expression in complex tissues at 10-micron resolution.