Author

Raquel Ortega

University of Colorado BoulderORCID 0000-0003-1954-0704Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Erin Taylor· 2 shared Nausica ArnoultiD· 2 shared Benjamin Guy BitleriD· 1 shared Benjamin J. T. Dodd· 1 shared Benjamin NebenfuehriD· 1 shared Bruce Proctor· 1 shared Clara M. Stiefel· 1 shared Colin SempeckiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Erin Taylor

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJun 9, 2025

PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining during mitosis.

Raquel Ortega, Erin Taylor, Sophie M. Whitehead…·Nausica Arnoult

This study shows PARP1 and PARP2 are not required for MMEJ during mitosis, challenging previous assumptions and supporting combinatorial PARPi/MMEJi therapy in HR-deficient cancers.

DOI 10.1101/2025.06.09.658719

experimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedJun 3, 2024

Fate of telomere entanglements is dictated by the timing of anaphase midregion nuclear envelope breakdown

Rishi Kumar Nageshan, Raquel Ortega, Nevan J. Krogan, Julia Promisel Cooper

The paper shows that Rif1 delays nuclear envelope breakdown during anaphase, preventing resolution of telomere entanglements caused by Taz1 loss, leading to lethality.

3 citations

yeastexperimental assay

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Molecular BiologyMolecular CellPeer-reviewedApr 11, 2023

The APE2 nuclease is essential for DNA double strand break repairby microhomology-mediated end-joining.

Hubert Fleury, Myles K. MacEachern, Clara M. Stiefel…·Nausica Arnoult

This study identifies APE2 nuclease as a critical factor for MMEJ repair, showing its role in telomere fusion and DNA repair reporter assays.

53 citationstop 3%

DNA methylationstatistical model

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