Matthew John Payea

This study identifies cell-type-specific RNA isoform changes in aging mouse brain using single-cell and long-read sequencing, revealing altered coding potential and senescence markers in immune cells.

The paper introduces RNAkinet, a deep learning model that uses nanopore sequencing to analyze RNA dynamics and cis-regulatory elements at single molecule resolution.

The paper investigates how senescence affects the integrated stress response and secretory phenotype in human cells, finding that translational repression of ATF4 reduces stress response and enhances inflammation.

The paper identifies a new pathway in yeast where pre-tRNAs are degraded by the RTD pathway after nuclear export due to structural instability and increased availability.