Jonathan R. Krebs

This study identifies YAP/TAZ signaling in endothelial cells as a key mediator of abdominal aortic aneurysm formation and shows that pharmacological inhibition reduces AAA progression.

This study shows PCSK9 inhibitors reduce AAA growth by enhancing macrophage efferocytosis through MerTK-dependent mechanisms and altering lipid metabolism in the aortic wall.

This study shows that inhibiting ferroptosis with liproxstatin-1 reduces AAA formation by decreasing inflammation and aortic remodeling in mice.

This study shows RvD2/GPR18 signaling enhances M-MDSC function to reduce AAA formation by suppressing inflammation and vascular remodeling.