Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibition attenuates abdominal aortic aneurysm formation via enhanced macrophage-dependent efferocytosis
Michael J. Fassler, Adithan Aravinthan, Jeff Arni C. Valisno…·Gilbert R. Upchurch
This study shows PCSK9 inhibitors reduce AAA growth by enhancing macrophage efferocytosis through MerTK-dependent mechanisms and altering lipid metabolism in the aortic wall.