Michael J. Fassler

This study identifies YAP/TAZ signaling in endothelial cells as a key mediator of abdominal aortic aneurysm formation and shows that pharmacological inhibition reduces AAA progression.

This study shows PCSK9 inhibitors reduce AAA growth by enhancing macrophage efferocytosis through MerTK-dependent mechanisms and altering lipid metabolism in the aortic wall.

This study shows vitamin D3 deficiency worsens abdominal aortic aneurysm by increasing complement C3a activation, suggesting targeting this pathway could be a new treatment.

This paper shows that PD1/GPR37 signaling in macrophages enhances efferocytosis, reducing inflammation and preventing AAA formation and rupture.