Gang Xin

This study shows that PIM1 in macrophages enhances CD36 expression and function, promoting foam cell formation and atherosclerosis, and that targeting this pathway could reduce plaque progression.

This paper introduces EmitGCL, a deep-learning framework that predicts future metastasis in cancer with high accuracy, identifies biomarkers, and validates therapeutic targets.

This study identifies the MHC-I alpha3 domain-CD8 interaction as an inhibitory pathway that restrains CD8+ T-cell activation and maintains tolerance in vivo.

This study identifies Aiolos as a negative regulator of antigen-inexperienced, virtual memory CD8+ T cells, showing increased TVM cell numbers and function in its absence.

MarsGT identifies rare cell populations in multi-omics single-cell data, outperforming existing tools and revealing novel biological insights in human and mouse datasets.

LRT integrates scTCR-seq and scRNA-seq data to infer T cell trajectories by combining clonal relationships with transcriptomic profiles.

DeepMAPS infers biological networks from single-cell multi-omics data using a heterogeneous graph transformer, outperforming existing tools in cell clustering and pathway prediction.