Hyeongseon Jeon

Circular Data Analysis for Spatial Omics

The paper provides guidance on analyzing circular data in spatial omics, using case studies to illustrate key considerations and methods.

Identification of TAP2 protein variants resistant to inhibition by the HSV1 ICP47 protein

The paper identifies TAP2 protein variants resistant to HSV1 ICP47 inhibition, which could lead to new antiviral therapies.

Multiplexed functional analysis of TAP2 variants in regulating MHC-I cell surface abundance reveals overexpression of PLK1 downregulates antigen presentation.

The paper functionally screens TAP2 variants to show PLK1 overexpression reduces MHC-I surface abundance by phosphorylating TAP2, impairing antigen presentation in cancer cells.

spaDesign: A Statistical Framework to Improve the Design of Sequencing-based Spatial Transcriptomics Experiments

spaDesign provides a statistical framework to optimize sequencing depth in spatial transcriptomics experiments by simulating data and estimating required sequencing depth for detecting spatial domains.

LRT: T Cell Trajectory Inference by Integrative Analysis of Single Cell TCR-seq and RNA-seq data

LRT integrates scTCR-seq and scRNA-seq data to infer T cell trajectories by combining clonal relationships with transcriptomic profiles.

Defining transcriptomic niches in human fibrotic lung with multi-sample spatial transcriptomics analysis using the MAPLE algorithm

The paper uses spatial transcriptomics and the MAPLE algorithm to analyze fibrotic lung tissue, identifying spatial biomarkers and fibrotic programs in IPF.