Paul D. Soloway

This study identifies common and distinct chromatin accessibility changes in adipose tissue from mice exposed to cold or Adrb3 agonists, revealing unique functional consequences of these stimuli on lipid composition and thermogenesis.

This study uses single-cell ATAC sequencing and lipid profiling to show that bariatric surgery alters chromatin accessibility and fatty acid profiles in adipose tissue, suggesting a metabolic shift mediated by Scd1.

The paper introduces methyl-ATAC-seq (mATAC-seq) to simultaneously measure open chromatin and DNA methylation, eliminating the need for separate assays.

The paper uses sci-ATAC-seq to analyze cortical cells in Ts65Dn mice, finding reduced excitatory neurons and increased interneurons, along with changes in chromatin accessibility related to transcription factors.

The paper investigates the role of pitRNA and its tandem repeats in directing DNA methylation at the Rasgrf1 locus, showing that pitRNA alone is insufficient and the repeats have cis-acting roles beyond transcriptional control.