BioengineeringAdvanced MaterialsPeer-reviewed
High-throughput in vivo screening using barcoded mRNA identifies lipid nanoparticles with extrahepatic tropism for cancer immunotherapy
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu…·Michael J. Mitchell
Author
Roman Spektor
Cornell UniversityORCID 0000-0003-4467-5942Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2019-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 18 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- GenomicsCommunications BiologyPeer-reviewed
Remodeling of gene regulatory networks underlying thermogenic stimuli-induced adipose beiging
Seo Yeon Lee, Abigail M. Benvie, Hui Gyu Park…·Paul D. Soloway
This study identifies common and distinct chromatin accessibility changes in adipose tissue from mice exposed to cold or Adrb3 agonists, revealing unique functional consequences of these stimuli on lipid composition and thermogenesis.
22 citations - GenomicsPLoS ONEPeer-reviewed
Single-cell Chromatin Accessibility and Lipid Profiling Reveals a Metabolic Shift in Adipocytes Induced by Bariatric Surgery
Blaine Harlan, Hui Gyu Park, Roman Spektor…·Paul D. Soloway
This study uses single-cell ATAC sequencing and lipid profiling to show that bariatric surgery alters chromatin accessibility and fatty acid profiles in adipose tissue, suggesting a metabolic shift mediated by Scd1.
2 citations - GenomicsGenome ResearchPeer-reviewed
methyl-ATAC-seq measures DNA methylation at accessible chromatin
Roman Spektor, Nathaniel D. Tippens, Claudia A. Mimoso, Paul D. Soloway
The paper introduces methyl-ATAC-seq (mATAC-seq) to simultaneously measure open chromatin and DNA methylation, eliminating the need for separate assays.
42 citations - GenomicsbioRxivPreprint
Single cell ATAC-seq identifies broad changes in neuronal abundance and chromatin accessibility in Down Syndrome
Roman Spektor, Jee Won Yang, Seo Yeon Lee, Paul D. Soloway
The paper uses sci-ATAC-seq to analyze cortical cells in Ts65Dn mice, finding reduced excitatory neurons and increased interneurons, along with changes in chromatin accessibility related to transcription factors.
13 citations