Claudia A. Mimoso

This study identifies elongin B as a key regulator of Pol2 elongation in H3K27M-mutant diffuse midline glioma, showing its role in maintaining chromatin and transcriptional dysregulation.

This study identifies MECOM's role in blocking differentiation via CEBPA repression, showing that targeting this regulatory element can promote differentiation and reduce leukemia burden in AMLs.

The paper investigates how the Restrictor complex suppresses non-coding RNA transcription by slowing RNA polymerase II elongation, preventing transcriptional interference at divergent promoters.

This study shows Notch1 activates transcription by releasing paused RNA Pol II without requiring chromatin accessibility changes.

The paper identifies sequence features that influence RNA polymerase II elongation potential by screening thousands of transcribed regions using INSERT-seq.

The paper shows co-transcriptional splicing and 3' end cleavage are functionally linked in mammalian erythropoiesis, with splicing delays and intron retention affecting cleavage efficiency.

The paper introduces methyl-ATAC-seq (mATAC-seq) to simultaneously measure open chromatin and DNA methylation, eliminating the need for separate assays.