Pantelis Tsoulfas

This study characterizes the cellular tropism and temporal dynamics of AAV2-retro-mediated gene delivery in the adult mouse retina following intravitreal injection, finding efficient and specific targeting of outer retinal cells.

This study delivers hyper-IL-6 to spinal cord neurons using retrograde AAV, activating Stat3 but causing severe tremors and weight loss in mice.

This study shows that Sox11 overexpression in mature corticospinal tract neurons reactivates embryonic growth-related gene expression, suggesting its potential to promote axon regeneration.

This study shows that cervical SCI in rats impairs aerobic fitness, muscle endurance, and cardiovascular function through various stress tests.

This study profiles the transcriptional response of supraspinal cell types to spinal injury in mice, finding that CST neurons respond more strongly to injuries closer to the brain than to distant spinal injuries.

The paper uses single nuclei RNA sequencing to identify transcriptional profiles and marker genes for supraspinal neurons projecting to the lumbar spinal cord in mice.

The paper quantifies the supraspinal connectome in mice to identify anatomical correlates of functional recovery after spinal injury.

The paper demonstrates the use of AAV-PHP.S to efficiently target and transduce cranial ganglion sensory neurons, enabling visualization and functional analysis of their connectivity.

This study uses single cell RNA sequencing to analyze cellular heterogeneity and interactions in injured mouse spinal cord, identifying novel subpopulations and signaling pathways involved in angiogenesis, gliosis, and fibrosis.

This study uses retrograde viral vectors and 3D microscopy to map supraspinal connectivity in the spinal cord and demonstrate their therapeutic potential.