Jae K. Lee

AGC kinase homology requires and enables co-targeting for CNS regeneration

The paper shows co-inhibition of AGC kinases enhances CNS neuron regeneration and identifies TMP-316 as a drug candidate achieving this in a rat model.

Molecular pathology of acute spinal cord injury in middle-aged mice

This study compares transcriptomic and histopathological outcomes in young and middle-aged mice after spinal cord injury, finding similar recovery but differences in cell subpopulations.

OrthologAL: A Shiny application for quality-aware humanization of non-human pre-clinical high-dimensional gene expression data

OrthologAL converts non-human transcriptomics data to human orthologs for drug discovery, preserving data structure and enabling use with human-annotated databases.

A Systematic Evaluation of the Computational Tools for Ligand-receptor-based Cell-Cell Interaction Inference

This study evaluates nine computational tools for predicting ligand-receptor-based cell-cell interactions using mouse single-cell RNA sequencing data.

Single cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord

This study uses single cell RNA sequencing to analyze cellular heterogeneity and interactions in injured mouse spinal cord, identifying novel subpopulations and signaling pathways involved in angiogenesis, gliosis, and fibrosis.

Fibrotic scar after experimental autoimmune encephalomyelitis inhibits oligodendrocyte differentiation

This study shows that fibroblasts contribute to an inhibitory environment in EAE by promoting fibrosis, which hinders oligodendrocyte differentiation and remyelination.