GeneticsbioRxivPreprint
Cell autonomous inflammation in VEXAS is mediated by cGAS-STING
Samuel J. Magaziner, Jason C. Collins, Brecca Miller…·David B. Beck
This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.
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